Laboratory

As the unique INSERM-UNISTRA joint unit dedicated to Regenerative Nanomedicine, we bridge two complementary fields with a clear, patient-centered mission to develop transformative technologies for health. Nanomedicine harnesses materials and devices engineered at the molecular scale to deliver therapeutics with unprecedented precision, targeting specific cells and tissues while minimizing systemic effects. Regenerative Medicine activates the body’s innate repair mechanisms through stem cells, advanced biomaterials and tissue engineering to restore damaged or diseased tissues to full function.

By integrating these approaches, we develop next-generation, patient-focused solutions in which nanoscale technologies actively guide, accelerate and personalize tissue repair and regeneration. Our strength lies in our ability to adapt and tailor health technologies across a wide spectrum of pathologies. By designing modular and scalable nanomedicine and regenerative platforms, we customize therapeutic strategies to address disease-specific mechanisms, tissue contexts, and patient needs. This adaptability enables precise, personalized interventions with broad translational potential, accelerating the path from innovation to clinical impact.

At the heart of our work lies a singular mission: advancing Regenerative Nanomedicine and Health Technologies. We develop advanced therapeutics that combine ATMPs, stem cell therapies and targeted cell therapy platforms to precisely modulate tissue repair, immune responses and disease pathways. Nanotechnology and delivery systems enable precision nano-formulations, therapeutic microvesicles and biomarker-driven strategies to guide interventions directly to diseased cells while monitoring responses in real time. Complementing these approaches, next-generation medical devices and tissue engineering scaffolds provide structural support, facilitate organ repair and create microenvironments that enhance regeneration.

Our research integrates innovative 3D models, organoids and bio-printed tissues to replicate complex microenvironments, study heterogeneity and overcome therapeutic resistance in cancer, inflammatory, gastric and intestinal pathologies. By combining these platforms with patient-specific secretomes and microenvironment-focused strategies, we design therapies that are not only precise but adaptive to disease context and individual patient biology. Across oncology, inflammatory bowel disease and lung pathologies, our integrated approach translates advanced regenerative and nano-based technologies into personalized, high-impact solutions for health.